有和无内分泌分化大肠癌P53和表皮生长因子受体表达的比较研究

 目的：研究大肠癌内分泌分化与P⁵³表皮生长因子受体（EGFR）表达的关系及意义。方法：采用免疫组织化学ABC法，检测79例大肠癌手术切除组织中嗜铬蛋白A（CGA），P⁵³及EGFR的表达变化。结果：大肠癌组织中CGA，P⁵³及EGFR的表达率分别为：35.4％（28/79〕，60.8％(48/79）和30.4％（24/79），有内分泌分化的大肠癌P⁵³表达率及其免疫阳性细胞数分别为78.6％（22/28）和984.3士702.0/mm²，无内分泌分化者分别为51.0％和589.5士489.5/mm²，前者明显高于后者（P53及EGFR的表达明显高于无内分泌分化者，提示P⁵³及EGFR的表达可能与大肠癌的内分泌分化有关

A control study on the expression of P~(53) and EGFR in colorectal carcinoma with and without endocrine differentiation

To evaluate the relationships and their significance between endocrine differentiation and P⁵³Protein or epidermal growth factor receptor(EGFR)expression in colorectalcarcinoma. Methods: Expression of chromogranin A (CGA), P⁵³and EGFR weredetectedin 79surgical specimen using immunohistochemistry ABC technique Results: The incidences ofCGA, P⁵³and EGFR expression in the cancerous tissues were 35.4 % (28/79), 60.8 % (48/79 )and 30.4 % (24/79), respectively, The expressive rate and the number of P⁵³ immunostainingtumor cells in the tumor lesions with endocrine differentiation were 78.6 % (22/28) and 984.3±702/mm² and in the samples without endocrine differentiation 51.0% and 589.5±489.5/mm². The differences of P⁵³expression between the two groups were significant (P0.025;PO.05). The rate of EGFR expression in the tumor with and without endocrine differentiation were 46.4% (13/28) and 21.6 % (11/51 ),respectively. Their difference was also statistically significant (P0.025 ). Conclusion: The expression of P⁵³ and EGFR are statisticallyhigher in the colorectal cancer with endocrine differentiation than that in the cases withoutendocrine differentiation. It indicates that the explession of P⁵³ and EGFR may be correlatedwith the endocrine differentiation of colorectal carcinoma.