| MMP-9与TIMP-1在脑胶质瘤中的表达及临床意义 |
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| 引用本文： | 孙高令,张伟,肖航,白云安,袁训辉. MMP-9与TIMP-1在脑胶质瘤中的表达及临床意义[J]. 立体定向和功能性神经外科杂志, 2011, 0(1): 41-43 |
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| 作者姓名： | 孙高令 张伟 肖航 白云安 袁训辉 |
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| 作者单位： | 山东潍坊市益都中心医院神经外科 |
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| 摘 要： | 目的探讨基质金属蛋白酶MMP-9和金属蛋白酶抑制剂TIMP-1在人脑胶质瘤中的表达及其与肿瘤临床生物学行为的关系。方法采用免疫组织化学PV9000通用二步法检测50例脑胶质瘤组织中MMP-9与TIMP-1的表达情况。结果随胶质瘤恶性程度增高MMP-9表达增强,TIMP-1表达减低,两者具有相关性,且差别具有统计学意义。结论 MMP-9、TIMP-1在胶质瘤中的表达与其恶性程度具有相关性,并可能评估其预后。
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| 关 键 词： | 基质金属蛋白酶 金属蛋白酶类组织抑制剂 胶质瘤 免疫组织化学 |
Research of Expression of MMP-9 and TIMP-1 in Glioma |
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| Affiliation: | Sun Gaoling,Zhang Wei,Xiao Hang,et al.Department of Neurosurgery,Yidu Central Hospital of Weifang,Wei Fang City,262500 China |
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| Abstract: | Objective To investigate the expressions of matrix metalloproteinase-9(MMP-9),tissue inhibitor of metalloproteinase-1(TIMP-1) in glioma and their relationship with the clinical biological behavior of the tumor.Methods Expressions of MMP-9,TIMP-1 were detected in 50 cases underwenting glioma by immunohistochemical staining method.Results The expression of MMP-9 increases while TIMP-1 decreases with the malignancy of glioma increasing.The difference of the expressions of the two proteins was significant(P<0.05).Conclusion The expression of MMP-2 and TIMP-1 are correlated with the malignancy of glioma,the prognosis of which may also be estimated at the same time. |
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| Keywords: | Metalloproteinase Tissue inhibitor of metalloproteinase Glioma Immunohistochemistry |
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