Human T-cell leukemia virus type II: primary structure analysis of the major internal protein, p24 and the nucleic acid binding protein, p15 |
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Authors: | S G Devare Y Kim J L Fox J Getchell C Cabradilla V S Kalyanaraman |
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Institution: | 1. Molecular Biology Department, Abbott Laboratories, Abbott Park, N. Chicago, Illinois, 60064 USA;2. Molecular Virology Branch, Centers for Disease Control, Atlanta, Georgia, 30383 USA |
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Abstract: | The 24,000-molecular-weight major internal protein (p24) and the 15,000-molecular-weight nucleic acid binding protein (p15) of human T-cell leukemia virus type II (HTLV-II) were subjected to amino acid composition and amino-terminal amino acid sequence analysis. A comparison of amino acid composition of p24 and p15 of HTLV-II with those of the analogous proteins of HTLV-I revealed that these two proteins share overall similarity. Further, alignment of the amino-terminal amino acid sequence for the first 27 residues of p24 and 34 residues of p15 from HTLV-II showed extensive sequence homology with analogous proteins of HTLV-I. These data suggest that although disease associated with HTLV-I is malignant T-cell leukemia and that associated with HTLV-II is a relatively benign variant of hairy-cell leukemia, HTLV-I and HTLV-II are closely related to each other, at least in their gag-gene-encoded sequences. |
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Keywords: | Author to whom requests for reprints should be addressed |
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