残留卵巢综合征102例分析

目的 探讨全子宫切除术中保留一侧或双侧卵巢，术后残留卵巢综合征(ROS)的发生率、发病机制及治疗方法。方法 1996年1月～2000年12月，我院因良性疾病行全子宫切除术共1798例，其中发生ROS102例，均有明显的临床症状，且经超声检查证实，排除囊、实性肿块，一旦诊断明确应首选避孕药治疗，由门诊专人随访。测定39例ROS患者(研究组)及32名月经规则的健康妇女(对照组)的女性激素(于月经第12天抽取静脉血测定)。结果 102例ROS中，54例服药后症状消失，肿块缩小；22例症状明显好转，肿块缩小；13例药物治疗失败改用手术治疗；13例失访。研究组与对照组女性激素的差异无显著性。结论 全子宫或次全子宫切除术中保留一侧或双侧卵巢时可发生ROS，ROS妇女的卵巢功能基本在正常水平，一旦确诊可首先使用抑制卵巢药物治疗。

Analysis of residual ovary syndome:a report of 102 cases

Objective To appraise the incidence,pathogenesis and therapy of residual ovary syndome(ROS) after hysterectomy.Methods 10% of the causes of ROS were observed in 1798 cases of hysterectomy in our hospital from January 1996 to December 2000. All of them showed significant clinical symptoms with exclusion of cystic or solid masses by B mode ultrasound. Once diagnosed,contraceptive was given as the treatment of first choice. Persistent symptoms and suspicious ovarian tumor mass should arouse the necessity of operation. Female hormones were tested in 39 ROS patients and 32 controls using venous blood drawn one week after menses.Results Symptoms relieved and regression of the mass were seen in 54 case with significant improvement in 22, failure of therapy turned to resection in 13 and loss of follow up also in 13.No significant difference was revealed in female hormone level in ROS patients and that of healthy controls.Conclusion ROS may occur in woman who reserves one or both ovaries after partial panhysterectomy. The ovarian function of ROS' woman remains normal, once diagnosed , ovarian hormones inhibitory drugs should be tried first.