Treatment with rhG-CSF for osteomyelitis in a patient with p47-phox-deficient chronic granulomatous disease |
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| Authors: | H. Isotani Y. Fukumoto H. Kawamura M. Sasada K. Hattori T. Fujiwara Y. Kobayashi |
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| Affiliation: | (1) Department of Internal Medicine, Hirakata City Hospital, 2-14-1 Kinyahonmachi, Hirakata City, Osaka 573, Japan, JP;(2) College of Medical Technology, Kyoto University, 53 Shogoin-Kawaharacho, Kyoto City, Kyoto 606, Japan, JP;(3) Department of Pediatrics, Kansai Medical University, 10–15 Fumizonocho, Moriguchi City, Osaka 570, Japan, JP |
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| Abstract: | A 24-year-old woman with osteomyelitis was diagnosed as having p47-phox-deficient chronic granulomatous disease (CGD). The patient showed a marked deficiency of p47-phox, which is very rare in Japan. As the clinical response to various antibiotics including sulfamethoxazole-trimethoprim was not satisfactory, we added recombinant human granulocyte colony-stimulating factor (rhG-CSF) to the treatment protocol. We report the beneficial clinical course of the patient, together with the effect of rhG-CSF on the granulocyte function, and the present report indicates that rhG-CSF is useful for the treatment of antibiotic-resistant infection in the variant type of p47-phox-defective CGD. Received: 24 June 1997 / Accepted: 6 August 1997 |
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| Keywords: | Chronic granulomatous disease p47-phox deficiency G-CSF Superoxide anion (O2 ) Osteomyelitis |
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