原发性肝癌门静脉癌栓形成相关因素分析

目的　探讨原发性肝癌 (PHC)患者门静脉癌栓形成 (PVTT)的相关因素。方法　回顾性分析PHC 86例 ,彩色多普勒超声检查PVTT ,总结PVTT与PHC患者年龄、肿瘤类型、肝硬化基础及血清乙型肝炎表面抗原(HBsAg)和甲胎蛋白 (AFP)的相关性。 结果　 86例PHC中合并PVTT 2 4例 ,其中年龄在 4 0岁以下者占 4 1.7%。弥漫型、结节型和块状型PHC的PVTT发生率分别为 75 .0 % ,2 6 .3%和 2 0 .0 % ,有肝硬化基础或HBsAg阳性病例的PVTT发生率显著高于无肝硬化基础或HBsAg阴性病例 (P <0 .0 1) ,而AFP阳性与阴性病例的PVTT发生率差异无统计学意义。结论　年轻人、弥漫型、伴有肝硬化基础和HBsAg阳性的PHC ,PVTT发生率高

Relative factors of portal vein tumor thrombosis in patients with primary hepatic carcinoma

Objective To investigate the relative factors of portal vein tumor thrombosis (PVTT) in patients with primary hepatic carcinoma (PHC). Methods A total of 86 patients with PHC were included in this retrospective study. The presence of PVTT was determined by color Doppler ultrasound examination. The relationship between PVTT and clinicopathological characteristics including age, tumor type, accompanied with the basis of liver cirrhosis, state of HBsAg and serum alpha-fetoprotein (AFP) was summarized. Results Among the 86 patients with PHC, 24 cases had PVTT, and 40% among the patients with PVTT were younger than 40 years of age. PVTT incidences were 75.0%, 26.3% and 20.0% in diffuse, nodular and massive type of PHC respectively. PVTT incidence was significantly higher in the PHC with the basis of liver cirrhosis and HBsAg-positive subjects than that without basis of liver cirrhosis and HBsAg-negative subjects (P< 0.01), whereas there was no significant difference in the AFP-positive and AFP-negative subjects.Conclusion PVTT occurred more commonly in the younger, diffuse type, accompanied with the basis of liver cirrhosis or HBsAg-positive subjects of all PHC.