血浆同型半胱氨酸与脑梗死及颈动脉硬化相关性的研究

目的探究血浆同型半胱氨酸与颈动脉硬化、脑梗死的相关性。方法随机选取并回顾性分析2011年6月至2012年1月于我院治疗脑梗死患者76例(研究组)及76例同期健康体检者(对照组)。对比两组患者同型半胱氨酸(Hcy)水平、颈动脉内膜-中层厚度(IMT)。结果研究组高同型半胱氨酸血症患者明显高于对照组差异存在统计学意义(P<0.05),研究组Hcy、叶酸水平明显高于对照组(P<0.05)。研究组76例患者中44例出现颈动脉硬化,按照IMT、PSV将研究组患者分为颈动脉梗死轻度组、中度组、重度组。各组Hcy、IMT存在相关性,中度组及重度组Hcy、IMT水平均显著高于轻度组,存在统计学意义(P<0.05),且两者亦存在统计学差异(P<0.05)。结论血浆Hcy水平与动脉膜粥样硬化有一定联系,在一定程度上可以提示脑梗死进展和治疗情况。同时对于动脉粥样硬化的早期干预具有指导作用。

The Study of Relationship of Homocysteine with Cerebral Infarction and Carotid Artery Arteriosclerosis

Objective To discuss the relationship of homocysteine with cerebral infarction and carotid artery arteriosclerosis.Methods Choosed 76 patients of cerebral infarction as study group and 76 healthy people as controlled group from Jun.2011 to Jan.2012,compared level of homocysteine,IMT.Results The homocystinemia patients in study group were higher than controlled group（P.0.05）.And the level of Hcy,folic acid in study group was higher than controlled group（P0.05）.There were 44 patients occured carotid artery arteriosclerosis in study group,and divided into mild group,moderate group,and severe group as level of IMT,PSV.There was significant difference in these three groups in Hcy,IMT（P0.05）.Conclusion There was relationship in homocysteine with cerebral infarction and carotid artery arteriosclerosis to point us to prevention.