| 乳癌根治术后静脉自控镇痛曲马多的最佳负荷剂量 |
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| 引用本文： | 荣健,叶升,黄文起.乳癌根治术后静脉自控镇痛曲马多的最佳负荷剂量[J].肿瘤防治研究,2004,31(10):650-652. |
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| 作者姓名： | 荣健 叶升 黄文起 |
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| 作者单位： | 1. 510000,广州,中山大学第一附属医院麻醉科
2. 广州铁路中心医院肿瘤科 |
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| 摘 要： | 目的 寻求乳癌根治术后静脉自控镇痛曲马多的最佳负荷剂量。方法 80例ASAⅠ～Ⅱ级女性乳癌病人 ,每组 2 0例 ,随机分为Ⅰ～Ⅳ组。各组分别在手术结束前 30min ,静脉注射曲马多负荷剂量1.2 5mg/kg、2 .5mg/kg、3.75mg/kg、5mg/kg。观察各组患者在PACU中疼痛、恶心、呕吐、镇静的发生情况。结果 在PACU中 ,为达到基础VAS评分≤ 3,Ⅰ组使用曲马多高达 8.8± 2 .91ml;95 % (19/ 2 0 )得使用PCA。Ⅲ组有 1例患者 (37min)、Ⅳ组有 2例患者 (39min、6 2min)发生苏醒延迟。Ⅲ组和Ⅳ组患者 2级镇静发生率分别为 30 %和 35 % (P <0 .0 5 )。结论 曲马多用于乳癌根治术后自控镇痛效果满意 ,手术结束前 30min 2 .5mg/kg曲马多的静脉负荷剂量具有与 3.75mg/kg和 5mg/kg等同的镇痛效果 ,同时并发症较轻
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| 关 键 词： | 曲马多 乳癌根治术 自控镇痛 负荷剂量 |
| 文章编号： | 1000-8578(2004)10-0650-03 |
| 收稿时间： | 2004-7-27 |
| 修稿时间： | 2004-8-17 |
Tramadol 2.5mg·kg-1 Appears to Be the Optimal Intraoperative Loading Dose before Patient-controlled Analgesia |
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| RONG Jian,YE Sheng,HUANG Wen-qi.Tramadol 2.5mg·kg-1 Appears to Be the Optimal Intraoperative Loading Dose before Patient-controlled Analgesia[J].Cancer Research on Prevention and Treatment,2004,31(10):650-652. |
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| Authors: | RONG Jian YE Sheng HUANG Wen-qi |
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| Institution: | RONG Jian,YE Sheng,HUANG Wen-qi 1.Department of Anesthesia,The First Affiliated Hospital,Zhongshan University,Guanzhou 510000,China,2.Department of Cancer,Guangzhou Railway Hospital |
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| Abstract: | Objective To identify the most appropriate inital dose to improve the quality of tramadol PCA.Methods During general anesthesia,80 patients undergoing radical operation of mastocarcinoma were randomly allocated to receive 1.25 mg/kg (Group Ⅰ), 2.5 mg/kg(Group Ⅱ), 3.75 mg/kg (Group Ⅲ),5mg/kg(Group Ⅳ) tramadol.The titration of additional tramadol by PCA every five minutes was performed in the postanesthesia care unit (PACU) until the visual analogue scale (VAS) score was≤3.An investigator blinded to ... |
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| Keywords: | Tramadol Radical operation of mastocarcinoma PCA Loasing dose |
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