雷公藤双层片对系统性红斑狼疮治疗作用及机制的实验研究

目的：探讨雷公藤双层片治疗系统性红斑狼疮(SLE)的作用及机制，为临床应用提供实验依据。方法：采用兔Arthus反应，大鼠佐剂性关节炎模型进行雷公藤双层片治疗SLE的实验研究。结果：雷公藤双层片对家兔Arthus反应有明显的抑制作用。使Arthus反应家兔循环免疫复合物(CIC)含量以及血清IL-2水平明显下降。雷公藤双层片明显抑制大鼠佐剂性关节炎的继发病变，使佐剂性关节炎大鼠脾重量减轻，肾上腺重量增加。血浆皮质醇水平升高。结论：雷公藤双层片对SLE有明显的治疗作用，其机制可能与它降低血清IL-2水平。抑制Th细胞和B细胞功能，导致循环免疫复合物减少有关，亦与其通过类激素样抗炎作用，减轻机体炎症反应有关。

Experimental Studies on the Treatment of SLE with Tripterygium wilfordii Dilayer Tablet and Its Mechanisms

Objective: To investigate the mechanism of Tripterygium wilfordii Dilayer Tablet in treating SLE in order to make verification of that Tripterygium wilfordii Dilayer Tablet is an effective drug used in the treatment of SLE. Methods:The response of Arthus in rabbits and Adjuvant arthritis in rats were observed. Results:Our results shows that: (1) Tripterygium wilfordii Dilayer Tablet can inhibit the response of Arthus and increase levels of serum CIC,serum IL-2 in rabbits.(2) Tripterygium wilfordii Dilayer Tablet had markedly inhibitory effect on secondary reaction of Adjuvant arthritis in rats.It increased the weight of adrenal and splen while decreasing the content of plasma hydrocortisone in rats of Adjuvant arthritis.Conclusion: Tripterygium wilfordii Dilayer Tablet has good effects on SLE. The mechanism of Tripterygium wilfordii Dilayer Tablet in the treatment of SLE not only owe to increasing levels of serum IL-2, inhibitory effect on Th cells and B cells function,which lead to decreasing levels of serum CIC,but also to its Anti-inflammatory action similar to that of hydrocortisone.