嗜酸性粒细胞和IL-5在鼻息肉中的表达及在发病中的作用

目的探讨嗜酸性粒细胞、IL-5在鼻息肉中的表达及其在发病中的作用。方法 43例变应性鼻炎、80例慢性鼻窦炎不伴鼻息肉、80例鼻息肉与60例健康对照志愿者作为本次研究对象。检测受试对象嗜酸性粒细胞计数、血清总IgE、白细胞介素5(IL-5)、嗜酸性粒细胞阳离子蛋白(ECP)水平。结果鼻息肉组IL-5、ECP、IgE水平及嗜酸性粒细胞计数均高于对照组(P0.05);Logistic分析显示IL-5、ECP、IgE水平与鼻息肉的预后、复发密切相关;Pearson's相关性分析显示鼻息肉组患者血清ECP水平与IL-5呈正相关(r=0.493,P0.05),血清ECP水平与IgE有弱相关(r=0.261,P=0.041)。结论嗜酸性粒细胞、IL-5在鼻息肉的发病中起到重要作用,同时不排除变态反应对病情的影响,治疗上均应给与重视。

Study on correlation of nasal polyps with eosinophil cationic protein and IL-5

Objective To explore the role of eosinophil and its expression of IL-5 in pathogenesis of allergic rhinitis,sinusitis and nasal polyps. Methods A total of 43 cases of allergic rhinitis,80 cases of chronic sinusitis without nasal polyps,80 cases of nasal polyps and 60 healthy volunteers served as controls were enrolled in this study. Eosinophil count,serum total IgE,IL-5 and eosinophil cationic protein（ ECP） were detected. Results Serum levels of IL-5,ECP and IgE and eosinophil count in patients with nasal polyps group were higher than those of control group（ P 〈0. 05）. Logistic analysis showed that ECP,IL-5 and IgE were closely related with prognosis and recurrence in patients with nasal polyps. In Nasal polyps group,Pearsonˊs correlation analysis showed that serum ECP and IL-5 had positive correlation（ r =0. 493,P 〈0. 05）,and serum ECP and IgE had weaker correlation（ r =0. 261,P =0. 041）. Conclusion Eosinophils and IL-5 play an important role in pathogenesis of nasal polyps,but it does not rule out allergic impact on the disease,and the treatment should be given with more attention.