| 反义寡脱氧核苷酸技术在分子影像中的应用 |
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| 引用本文： | 王金玉,武兆忠. 反义寡脱氧核苷酸技术在分子影像中的应用[J]. 国际放射医学核医学杂志, 2002, 33(1): 1-5. DOI: 10.3760/cma.j.issn.1673-4114.2009.01.001 |
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| 作者姓名： | 王金玉 武兆忠 |
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| 作者单位： | 医学影像实验室,广州医学院第二附属医院核医学科,510260; |
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| 摘 要： | 反义寡脱氧核苷酸(ASODN)技术是根据核酸杂交原理,设计针对特定靶序列的ASODN,从而抑制特定基因的表达.分子影像学是一门在细胞与分子水平对活体生物过程进行描述和测量的新兴交叉学科.ASODN技术以分子影像为技术平台,通过图像达到无创、实时、活体、特异、精细地直接显示细胞或分子水平的生理和病理过程.该文主要阐述ASODN的作用机制、ASODN的化学修饰、ASODN技术的进展及其在分子影像领域的应用.
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| 关 键 词： | 寡脱氧核苷酸,反义 分子诊断技术 |
Antisense oligodeoxynucleotides in the application of molecular imaging |
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| WANG Jin-yu,WU Zhao-zhong. Antisense oligodeoxynucleotides in the application of molecular imaging[J]. International Journal of Radiation Medicine and Nuclear Medicine, 2002, 33(1): 1-5. DOI: 10.3760/cma.j.issn.1673-4114.2009.01.001 |
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| Authors: | WANG Jin-yu WU Zhao-zhong |
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| Abstract: | Antisense oligodeoxynucleotide(ASODN) technology is based on nucleic acid hybridization principles, and designed for the specific target of ASODN sequence, thus to inhibit the expression of specific genes. Molecular imaging is the emerging cross-subject in cell and molecular level of living biological processes to describe and measure. Molecular imaging technology as a platform for ASODN technology to reach non-invasive, real-time, live, specific, detailed images directly through the display cells or molecular level physiological and pathological processes. This introductory chapter summarizes the role of ASODN mechanism, chemical modification, ASODN technology progress and ASODN technology in the field of molecular imaging applications. |
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| Keywords: | Oligodeoxynucleotide antisenseMolecular diagnostic technigues |
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