| Fuzheng Kang'ai decoction(扶正抗癌方) inhibits cell proliferation,migration and invasion by modulating mir-21-5p/human phosphatase and tensin homology deleted on chromosome ten in lung cancer cells |
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| 作者姓名： | LI Jinhua LIU Chunping ZHAO Yueyang WU Wanyin SUN Pengtao LI Longmei YANG Xiaobing ZHOU Yushu |
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| 作者单位： | 1. Department of Ultrasound, Guangdong Provincial Hospital of Chinese Medicine, the Second Affiliated Hospital of Guangzhou University of Chinese Medicine;2. Department of Ultrasound, Institute of Ultrasound in Musculoskeletal Sports Medicine, Guangdong Second Provincial General Hospital;3. State Key Laboratory of Dampness Syndrome of Chinese Medicine, Guangdong Provincial Hospital of Chinese Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine;4. Department of Hematology, Guangdong Provincial Hospital of Chinese Medicine, the Second Affiliated Hospital of Guangzhou University of Chinese Medicine;5. Department of Oncology, Clinical and Basic Research Team of TCM Prevention and Treatment of NSCLC, Guangdong Provincial Hospital of Chinese Medicine, the Second Affiliated Hospital of Guangzhou University of Chinese Medicine |
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| 基金项目： | Supported by China Postdoctoral Science Foundation (No. 2020M672745)；;the National Natural Science Foundation of China of China (No. 81503507:Exploring the Mechanism on Reversal of Gefitinib Resistance in Treating Non-Small Cell Lung Cancer by Fuzhengkangai Decoction base on miRNA-206/449a, 81974543:Research on Fuzheng kang’ai Formula Reversing the Drug Resistance to Gefitinib in Non-Small Cell Lung Cancer (NSCLC) via inducing Ferroptosis by Regulating Ferritin and 81803919:the Molecular Mechanism of Fuzheng Kang-ai Decoction Reversing EMT based on Crosstalk between Tumor and Its Microenvironment)； |
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| 摘 要： | OBJECTIVE: To elucidate the potential molecular mechanism by which Fuzheng Kang’ai decoction(扶正抗癌方, FZKA) inhibits proliferation, migration, and invasion of lung cancer cells. METHODS: Varying FZKA concentrations were used to manage lung cancer cells(A549 and PC9). We employed: cell counting kit-8(CCK-8) and plate clone formation assays to examine the cell viability; flow cytometry(FCM) to analyze the cycle arrest; transwell and woundhealing assays to assess the cell invasion and migration, resp...
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