血管内皮祖细胞生物学活性与血管内皮祖细胞捕获支架的研究进展

血管内皮祖细胞（EPCs）作为内皮细胞的前体细胞,具有"持续"的自我更新及定向分化的能力。EPCs捕获支架,如表面包被CD34^＋抗体的支架,能够识别循环血液中EPCs表面特异性性结合位点,捕获并促使EPCs归巢、分化为内皮细胞,参与病变血管内皮修复、促进血管新生、改善冠脉血流。EPCs的生物学活性是决定EPCs捕获支架临床应用的关键,本文从EPCs生物学特性、功能、冠状动脉微环境对EPCs的调控机制、EPCs捕获支架的研究进展等方面进行综述,探讨EPCs捕获支架的治疗价值。

Vascular endothelial progenitor cells:biological activity and capture stents

Vascular endothelial progenitor cells (EPCs) act as precursor cells of endothelial cells and have the ability of persistent self-renewal and directed differentiation. EPC capture stents, coated with CD34⁺ antibody, can recognize the exposed binding sites on the surface of EPCs, capture EPCs and promote them to home and differentiate into endothelial cells, participate in vascular endothelial repair, and facilitate angiogenesis to improve coronary blood flow. Studies have shown that the biological activity of EPCs is key to the clinical application of EPC capture stents. In this paper, we summarize the biological characteristics and function of EPCs and the regulatory effect of coronary artery microenvironment on EPCs, and review the progress in research of EPC capture stents to explore their therapeutic value.