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| 温热联合丝裂霉素、5-氟脲嘧啶对人胃癌细胞的体外效应 | |
| 引用本文： | 王亚旭,王代科,刘宝华. 温热联合丝裂霉素、5-氟脲嘧啶对人胃癌细胞的体外效应[J]. 中国普外基础与临床杂志, 1997, 0(1) |
| 作者姓名： | 王亚旭 王代科 刘宝华 |
| 作者单位： | 第三军医大学大坪医院野战外科研究所!重庆630042 |
| 摘 要： | 温热联合化疗、放疗及免疫治疗有协同抗癌作用,并能减轻对正常组织的副作用。本实验选择丝裂霉素C(MMC)及5-氟脲嘧啶(5-Fu)联合温热体外作用于人胃癌细胞株(MGC-803),检测其作用后活癌细胞百分计数、克隆形成率及存活分数,以观察温热联合MMC或5-Fu的细胞毒作用。结果表明:温热联合MMC有协同抗癌作用,且随温度的升高其作用逐渐增强,与单纯加温组比较有显著性差异(P<0.01);而温热联合5-Fu无协同抗癌作用,但与单纯加温组比较,在较低温度(37℃)时有显著性差异(P<0.01))。本实验结果为临床应用提供了依据。 |
| 关 键 词： | 温热 5-氟豚嘧啶 丝裂霉素 活癌细胞百分计数 克隆形成率 存活分数 |
EFFECTS OF HYPERTHERMIA COMBINED WITH MITOMYCIN, 5-FLUOROURACIL IN VITRO ON HUMAN GASTRIC CARCINOMA CELL |
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| Wang Yaxu,Wang Daike,Liu Baokua. EFFECTS OF HYPERTHERMIA COMBINED WITH MITOMYCIN, 5-FLUOROURACIL IN VITRO ON HUMAN GASTRIC CARCINOMA CELL[J]. Chinese Journal of Bases and Clinics In General Surgery, 1997, 0(1) | |
| Authors: | Wang Yaxu Wang Daike Liu Baokua |
| Affiliation: | Wang Yaxu,Wang Daike,Liu Baokua. Department ofGeneral Surgery,Research Institude of Surgery,Baping Hospital,The Third Military Medical Univer-sity,Chongqing 630042 |
| Abstract: | The antitumor activity of hyperthermia combined with mitomycin(MMC) ,5-fluorouracil (5-Fu) was observed in human gastric carcinoma cell line MGC-803. The study was aimed at understanding the percentage of living carcinoma cell,plating efficiency and survival fraction. The results showed that hyperthermia combined with MMC had a synergistic antitumor activity which was enhanced with temperature increasing, but it was not the same as hyperthermia combined with 5-Fu. In comparison with simple hyperthermia,the antitumor activity of hyperthermia combined with 5-Fu was enhanced at lower temperture. This results raises a basis of clinical practice. |
| Keywords: | Hyperthermia 5-Fluorouracil Mitomycin Percentage of living cells Plating efficiency Survival fraction |
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