| 赛庚啶的抗脂质过氧化作用 |
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| 引用本文： | 辛洪波,张宝恒.赛庚啶的抗脂质过氧化作用[J].中国药理学与毒理学杂志,1993(4). |
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| 作者姓名： | 辛洪波 张宝恒 |
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| 作者单位： | 北京医科大学基础医学院药理教研室，北京医科大学基础医学院药理教研室 北京 100083，北京 100083 |
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| 摘 要： | 赛庚啶(Cyp)对自氧化及自由基发生系统(FRGS)诱导离体大鼠心,肝,脑组织脂质过氧化作用均有明显的抑制效应,且对后者的抑制作用更为明显,其IC_(50)分别为2.56mmol·L~(-1),693,973μmol·L~(-1)和63,56,379μmol·L~(-1)Cyp对FRGS诱导离体大鼠心肌线粒体膜脂质过氧化作用也有一定的抑制作用,其IC_(50)为5.1mmol·L~(-1).结果提示Cyp的抗脂质过氧化作用与其清除氧自由基作用有关
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| 关 键 词： | 赛庚啶 自氧化 自由基发生系统 脂质过氧化 心肌 肝 脑 线粒体 |
Anti-lipid peroxidation effect of cyproheptadine |
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| XIN Hong-Bo,ZHANG Bao-Heng.Anti-lipid peroxidation effect of cyproheptadine[J].Chinese Journal of Pharmacology and Toxicology,1993(4). |
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| Authors: | XIN Hong-Bo ZHANG Bao-Heng |
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| Abstract: | Cyproheptadine(Cyp),anantiserotonin-antihistaminic agent with a significant calcium channel blocker activity,could significantly inhibit the lipid peroxidation(LPO)of heart,liver and brain homogenates induced by autoxidation and free radical generation system(FRGS,Fe2+ascorbic acid).The inhibitory effect of Cyp on the latter was obviously more potent than that on the former.Their IC50 were 2.56 mmol·L-1,693,973μmol·L-1 and 63,56,379μmol·L-1 respectively(r=0.9981,0.9995,0.9665,0.9792,0.9048,0.9828).Cyp also possessed certain inhibitory effects on the LPO of myocardial mitochondrial membrane in rats induced by FRGS(IC50=5.1 mmol·L-1,r=0.9920).The results suggest that anti-LPO action of Cyp may be related to its scavenging effects on oxygen free radicals. |
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| Keywords: | Cyproheptadine Autoxidation Free radical generation system Lipid peroxidation Heart Liver Brain Mitochondria |
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