融胚胎移植与新鲜胚胎移植多胎妊娠率的比较及相关因素分析

目的 比较冻融胚胎移植(FET)与新鲜胚胎移植的多胎妊娠率,分析多胎妊娠的相关因素,探讨移植不同数目的 胚胎对冻胚移植周期临床妊娠率的影响.方法 对经FET获得的1235例临床妊娠与经新鲜胚胎移植获得的1561例临床妊娠中的多胎妊娠进行回顾性分析.结果 多胎妊娠与移植周期(FET或新鲜胚胎移植)无关,而与女方的年龄、移植胚胎数、以及卵裂期胚胎或囊胚移植密切相关.在相同年龄段移植相同数目卵裂期胚胎时,FET 与新鲜胚胎移植的多胎妊娠率差异无统计学意义,增加移植胚胎数主要是增加了三胎妊娠率.＜35岁的妇女移植2个冻融胚胎的临床妊娠率可达36.1%.结论 多胎妊娠率与冻胚移植或新鲜胚胎移植无关.＜35岁的妇女移植2个冻融胚胎可以取得较好的妊娠率,同时可以降低FET周期的三胎妊娠率.

Comparison of multiple pregnancy rate following transfer of frozen-thawed or fresh embryos and analysis of related factors

Objective To compare the multiple pregnancy rates of frozen-thawed embryos transfer (FET)or fresh embryos transfer,analyze the factors related to multiple pregnancies after IVF and study pregnancy rates with different number of embryos transferred in FET cycle.Methods A retrospective analysis was performed upon multiple pregnancies from 1235 and 1561 clinical pregnancies conceived by FET or fresh embryo transfers.Results No correlation Was found between fresh or cryopreserved embryos transfer and multiple pregnancy rates.There were significant effects of woman's age,number of embryos transferred and stage of embryos upon multiple pregnancy rates.When the same number of cleavage-stage embryos Was transferred to women with the same age,twin pregnancy rate or triplet pregnancy rate was the same between FET and fresh cycles.Triplet pregnancy rate with three embryos transferred was significantly higher than that of two embryos transferred.In women under 35 years old,the pregnancy rate with two embryos transferred reached 36.1%.Conclusion Frozen-thawed embryos or fresh embryos transfer has no effect upon the multiple pregnancy rate.Women under 35 years old can achieve acceptable pregnancy rates when two cryopreserved embryos are transferred.It is helpful to reduce the triplet pregnancy rate.