| 潜溶剂和环糊精对难溶性药物的联合增溶作用 |
| |
| 引用本文： | 白雪莲,高永良. 潜溶剂和环糊精对难溶性药物的联合增溶作用[J]. 药学学报, 2006, 41(10): 950-955 |
| |
| 作者姓名： | 白雪莲 高永良 |
| |
| 作者单位： | 军事医学科学院,毒物药物研究所,北京,100850 |
| |
| 摘 要： | 目的研究潜溶剂和环糊精对难溶性药物的联合增溶作用。方法采用相溶解度法研究药物在不同混合溶剂中的相溶解度，利用已建立的数学模型对这种联合增溶作用作出评价和解释，非线性回归分析估计模型参数。结果两个难溶性药物的增溶模型判定系数R2分别为0.993和0.992，拟合效果很好，溶解度的实测值和模型预测值一致。结论该数学模型可以用于解释和预测潜溶剂和环糊精对难溶性药物的联合增溶作用。
|
| 关 键 词： | 潜溶剂 环糊精 难溶性药物 增溶 数学模型 |
| 文章编号： | 0513-4870（2006）10-0950-06 |
| 收稿时间： | 2006-01-05 |
| 修稿时间： | 2006-01-05 |
Combined effect of cosolvent and cyclodextrin on solubilization of insoluble drugs |
| |
| BAI Xue-lian,GAO Yong-liang. Combined effect of cosolvent and cyclodextrin on solubilization of insoluble drugs[J]. Acta pharmaceutica Sinica, 2006, 41(10): 950-955 |
| |
| Authors: | BAI Xue-lian GAO Yong-liang |
| |
| Affiliation: | Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, Beifing 100850, China |
| |
| Abstract: | Aim To investigate the combined effect of cosolvent and cyclodextrin(CD) on solubilization of insoluble drugs.Methods Phase-solubility method was applied to determine solubilization of two diterpenoids in cosolvent / cyclodextrin combinations.The combined effect was evaluated and explained with an established mathematical model,and the model parameters were calculated by means of nonlinear regression analysis.Results The strong agreement between the predicted and the observed solubility data supports the validity of the proposed model,with the determination coefficients of two regression models were 0.993 and 0.992,separately.Conclusion The validated mathematical model can be used to explain and predict the combined solubilization of the two insoluble drugs in different cosolvent systems. |
| |
| Keywords: | cosolvent cyclodextrin insoluble drug solubilization mathematical model |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
| 点击此处可从《药学学报》浏览原始摘要信息 |
|
点击此处可从《药学学报》下载全文 |
