| 葫芦巴总皂苷对链脲佐霉素诱导的糖尿病大鼠血小板活化的调节作用 |
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| 引用本文： | 卢芙蓉,秦铀,沈霖,熊鹏程,朱闽,刘建国,范恒,唐庆. 葫芦巴总皂苷对链脲佐霉素诱导的糖尿病大鼠血小板活化的调节作用[J]. 中国医院药学杂志, 2010, 0(5) |
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| 作者姓名： | 卢芙蓉 秦铀 沈霖 熊鹏程 朱闽 刘建国 范恒 唐庆 |
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| 作者单位： | 华中科技大学同济医学院附属协和医院中西医结合科; |
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| 基金项目： | 湖北省卫生厅资助课题[编号:鄂卫发2006(63)] |
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| 摘 要： | 目的:观察葫芦巴总皂苷(TFGs)对链脲佐霉素(STZ)诱导的糖尿病大鼠血小板活化的调控作用。方法:将正常大鼠和糖尿病大鼠随机分为未治疗对照组、治疗对照组、未治疗糖尿病组和治疗糖尿病组。两治疗组采用TFGs治疗4周。治疗结束后,分别检测大鼠体质量、血糖和胰岛素水平,采用流式细胞术检测各组大鼠血小板膜P选择素(CD62P)的表达,采用比浊法检测各组大鼠血小板最大聚集率。结果:与正常大鼠相比,糖尿病大鼠血糖明显升高,体质量和胰岛素水平显著下降,糖尿病大鼠经TFGs治疗后体质量明显增加,血糖下降,胰岛素水平升高;糖尿病大鼠血小板CD62P表达和血小板聚集率明显增高,经TFGs治疗后明显降低。结论:TFGs具有明显抑制STZ糖尿病大鼠血小板活化作用,是一种具有防治糖尿病血管病变作用的降糖药物。
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| 关 键 词： | 葫芦巴 血小板活化 血小板聚集 P选择素 链脲佐霉素 |
Regulating effect of Trigonella foenum-graecum L.saponin on platelet activation in streptozotocin induced diabetic rats |
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| LU Fu-rong,QIN You,SHEN Lin,XIONG Peng-cheng,ZHU Min,LIU Jian-guo,FAN Heng,TANG Qing. Regulating effect of Trigonella foenum-graecum L.saponin on platelet activation in streptozotocin induced diabetic rats[J]. Chinese Journal of Hospital Pharmacy, 2010, 0(5) |
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| Authors: | LU Fu-rong QIN You SHEN Lin XIONG Peng-cheng ZHU Min LIU Jian-guo FAN Heng TANG Qing |
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| Affiliation: | LU Fu-rong,QIN You,SHEN Lin,XIONG Peng-cheng,ZHU Min,LIU Jian-guo,FAN Heng,TANG Qing(Department of Integrated Chinese and Western Medicine,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Hubei Wuhan 430022,China) |
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| Abstract: | OBJECTIVE To explore the regulating effect of Trigonella foenum-graecum L. saponin (TFGs) on platelet activation in streptozotocin (STZ) induced diabetic rats.METHODS Both normal and diabetic rats were randomized to untreated group and treated group. In the two treated groups, TFGs were given via gavage for 4 weeks. After the treatment, the weight, blood glucose and insulin were measured. Meanwhile, flow cytometry was applied to determine P-selectin (CD62P) and turbidity method was adopted to test the plate... |
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| Keywords: | Trigonella platelet activation platelet aggregation p-selectin streptozotocin |
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