| 硝苯地平双层控释片的制备与体外释放 |
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| 引用本文： | 宁美英,周越,陈国军,梅兴国.硝苯地平双层控释片的制备与体外释放[J].中国医院药学杂志,2010(23). |
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| 作者姓名： | 宁美英 周越 陈国军 梅兴国 |
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| 作者单位： | 国家人口计生委科学技术研究所药物和医用材料研究中心;军事医学科学院毒物药物研究所; |
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| 基金项目： | 中国博士后科学基金资助项目(编号:20070420572) |
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| 摘 要： | 目的:采用渗透泵技术,制备硝苯地平控释片,并进行体外释放研究。方法:采用单因素筛选处方,分别考察含药层高分子聚氧乙烯(PEO)相对分子质量、含药层渗透压活性物质、助推层中高分子PEO相对分子质量、助推层的含量、压力、包衣膜厚度和释药孔孔径等因素对释放度的影响。结果:通过系列研究,结果表明,衣膜的完整性、能否释放药物以及释药速度的快慢主要受含药层中高分子PEO的相对分子质量、渗透压活性物质和助推层中高分子PEO相对分子质量、含药层和助推层体积比及压力、孔径、半透膜等因素的影响。结论:自制的硝苯地平双层渗透泵控释片在体外释药条件下释药稳定,在3～14h内零级特征明显(r=0.9995)、平均释药量约为8%/h、衣膜完整。
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| 关 键 词： | 硝苯地平 渗透泵片 释放度 |
Preparation and in vitro evaluation of nifedipine osmotic pump system |
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| NING Mei-ying,ZHOU Yue,CHEN Guo-jun,MEI Xing-guo.Preparation and in vitro evaluation of nifedipine osmotic pump system[J].Chinese Journal of Hospital Pharmacy,2010(23). |
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| Authors: | NING Mei-ying ZHOU Yue CHEN Guo-jun MEI Xing-guo |
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| Institution: | NING Mei-ying1,ZHOU Yue1,CHEN Guo-jun1,MEI Xing-guo2(1.Novel Drug Delivery and Biomaterial Research Center,National Research Institute for Family Planning,Beijing 100081,China,2.Beijing Institute of Pharmacology and Toxicology,Beijing 100850,China) |
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| Abstract: | OBJECTIVE To investigate the preparation and in vitro evaluation of nifedipine osmotic pump formulations were investigated.METHODS In present study,insoluble nifedipine was as the model drug to prepare the bi-layer osmotic pump tablets with polyethylene oxide(PEO) as the main excipients of the tablet core.The effects of many factors including formulation of drug layer,push layer and membrane,arts of tablet and the conditions of drug release on the release behavior of controlled release tablets were investig... |
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| Keywords: | nifedipine osmotic pump tablets drug release |
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