| 肿瘤抑制因子PTEN蛋白在自发性高血压大鼠主动脉平滑肌中的表达 |
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| 引用本文： | 严志强,衣昕,马红萍. 肿瘤抑制因子PTEN蛋白在自发性高血压大鼠主动脉平滑肌中的表达[J]. 南通医学院学报, 2002, 22(2): 130-131 |
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| 作者姓名： | 严志强 衣昕 马红萍 |
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| 作者单位： | 1. 南通医学院解剖教研室,南通,226001
2. 南通医学院机能实验室,南通,226001 |
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| 摘 要： | 目的：研究PTEN蛋白在雄性自发性高血压大鼠及SD大鼠主动脉中的表达。方法：取18周龄和26周龄雄性自发性高血压大鼠及同龄雄性SD大鼠主动脉石蜡包埋切片，免疫组织化学观察PTEN在主动脉平滑肌细胞中的表达。结果：SD大鼠主动脉平滑肌细胞中存在PTEN阳怀免疫反应产物。自发性高血压大鼠主动脉平滑肌细胞也存在PTEN阳性免疫反应产物，但免疫反应产物的染色强度明显低于SD大鼠。结论：SD大鼠主动脉平滑肌细胞PTEN高表达，自发性高血压大鼠主动脉平滑肌细胞PTEN表达呈下降趋势。提示PTEN可能在自发性高血压大鼠主动脉平滑肌细胞重塑过程中发挥作用。
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| 关 键 词： | PTEN蛋白 自发性高血压大鼠 主动脉 血管平滑肌细胞 免疫组化 |
| 文章编号： | 1000-2057(2002)02-0130-02 |
| 修稿时间： | 2002-03-01 |
EXPRESSION OF TUMOR SUPPRESSOR PTEN IN THE AORTA OF SPONTANEOUSLY HYPERTENSIVE RAT |
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| YAN Zhiqiang,YI Xin,MA Hongping. EXPRESSION OF TUMOR SUPPRESSOR PTEN IN THE AORTA OF SPONTANEOUSLY HYPERTENSIVE RAT[J]. ACTA Academiae Medicinae Nantong, 2002, 22(2): 130-131 |
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| Authors: | YAN Zhiqiang YI Xin MA Hongping |
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| Affiliation: | YAN Zhiqiang,YI Xin,1MA Hongping |
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| Abstract: | Objectives: To study expression of PTEN in aorta of both SD rats and SHR. Methods: The aorta from both SD rats and SHR aged at 18 and 26 weeks old were sectioned. The expression of PTEN was detected by immunohistochemistry. Results: Positive immunohistochemical production was located in VSMC of aorta from both SD rats and SHR. The intensity of positive immunohistochemical production from aorta of SD rats was stronger than that from SHR. Conclusion: Expression of PTEN is high in VSMC of aorta from SD rats. However, expression of PTEN in VSMC of aorta from SHR decreases. These results imply that PTEN may play a role in VSMC remodeling of aorta of SHR. |
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| Keywords: | PTEN Spontaneously Hypertensive Rat Aorta Vascular Smooth Muscle Cell Immunohistochemistry |
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