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| 阿片对人遗传物质的损伤效应 | |
| 引用本文： | 司晓娥,黄辰,王小平,宋土生,王艾英,陈圆圆.阿片对人遗传物质的损伤效应[J].中国药物依赖性杂志,1999,8(2):110-112. |
| 作者姓名： | 司晓娥 黄辰 王小平 宋土生 王艾英 陈圆圆 |
| 作者单位： | 1. 西安医科大学生物学及医学遗传学教研室,西安,710061 2. 西安市碑林区戒毒中心,西安,710048 3. 西安医科大学法医学院,西安,710061 |
| 摘 要： | 目的··：了解阿片对人体产生的细胞遗传学效应。方法··：运用微量人全血培养方法研究了阿片滥用者的外周血淋巴细胞染色体畸变、微核形成及细胞分裂指数。结果··：滥用阿片能够诱发人血淋巴细胞染色体畸变，提高微核形成率，并可使细胞分裂指数下降。随着滥用史的延长，其损害作用具有显著增加的趋势。结论··：阿片是人血淋巴细胞染色体的损伤因子。 |
| 关 键 词： | 阿片 淋巴细胞 微核 染色体畸变 细胞分裂指数 |
THE DAMAGE EFFECT OF OPIATE ON HUMAN HEREDITARY MATERIALS |
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| Si Xiao'e,Huang Chen,Wang Xiaoping,Song Tusheng,Wang Aiying,Chen Yuanyuan.THE DAMAGE EFFECT OF OPIATE ON HUMAN HEREDITARY MATERIALS[J].Chinese Journal of Drug Dependence,1999,8(2):110-112. | |
| Authors: | Si Xiao'e Huang Chen Wang Xiaoping Song Tusheng Wang Aiying Chen Yuanyuan |
| Abstract: | Objective: To study cytogenetics effect of the opiate on human body. Method: Use human whole blood culture to study the chromosomal aberration of opiate addicts, lymphocyte, lymphocytes micronucleus frenquency and mitotic index. Result: Abusing opiate induced human chromosomal aberration, increased lymphocytes micronucleus frenquency and declined mitotic index. With the increase of addiction history, the damage of hereditary materials had an obvious increasing trend. Conclusion:Opiate injures human blood lymphocyte chromosome. |
| Keywords: | opiate lymphocyte micronucleus chromosomal aberration mitotic index |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |