Spheciosterol sulfates, PKCzeta inhibitors from a philippine sponge Spheciospongia sp |
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| Authors: | Whitson Emily L Bugni Tim S Chockalingam Priya S Concepcion Gisela P Harper Mary Kay He Min Hooper John N A Mangalindan Gina C Ritacco Frank Ireland Chris M |
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| Affiliation: | Department of Medicinal Chemistry, University of Utah, Salt Lake City, Utah 84112, USA. |
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| Abstract: | Three new sterol sulfates, spheciosterol sulfates A-C (1-3), and the known sterol sulfate topsentiasterol sulfate E (4) have been isolated from the sponge Spheciospongia sp., collected in the Philippines. Structures were assigned on the basis of extensive 1D and 2D NMR studies as well as analysis by HRESIMS. Compounds 1-4 inhibited PKCzeta with IC50 values of 1.59, 0.53, 0.11, and 1.21 microM, respectively. In a cell-based assay, 1-4 also inhibited NF-kappaB activation with EC50 values of 12-64 microM. |
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