| Correlation of the expression of gonadotropin releasing hormone and its receptor in human gastric adenocarcinoma cell proliferation and differentiation |
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| 引用本文： | 孙绪德,柴伟,高昌俊,张贵和,陈蕾,黄威权. Correlation of the expression of gonadotropin releasing hormone and its receptor in human gastric adenocarcinoma cell proliferation and differentiation[J]. 中国临床康复, 2003, 7(6): 1000-1001,T004 |
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| 作者姓名： | 孙绪德 柴伟 高昌俊 张贵和 陈蕾 黄威权 |
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| 作者单位： | [1]DepartmentofAnesthesiology [2]DepartmentofHistologyandEmbryology,TangduHospital,FourthMilitaryMedicalUniversity,Xi‘an710033,ShaanxiProvince,China |
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| 摘 要： |
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| 关 键 词： | GnRH受体 表达 胃腺癌 细胞增殖 细胞分化 相关性 |
Correlation of the expression of gonadotropin releasing hormone and its receptor in human gastric adenocarcinoma cell proliferation and differentiation |
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| Abstract: | AIM:To inestigate the possible correlation of the expression of gonadotropin releasing hormone(GnRH) and its receptor with of proliferating cell nuclear antigen(PCNA) in human gastric adenocarcinoma cell proliferation and differentiation.METHODS:GnRH and its receptor and PCNA were detected in 30 gastric adenocarcinoma by immunohistochemical ABC technique.RESULTS:GnRH and its receptor had the same distribution pattern in gastric adenocarcinoma cells.The positive signal was found mainly in cytoplssm.The content of GnRH and its receptor immunoreative product in high differentiatied adenocarecinoma was the lowest(P&;lt;0.05).PCNA positive signal which was found mainly in nucleus was gradually abated along with the rainsing of the extent of the differentiation.THe differences were significant among the three groups(P&;lt;0.05).In human gastric adenocarcinoma.the expression of GnRH and its receptor was negative correlation with the expression of PCNA(r=0.9).CONCLUSION:GnRH might be involved in the regulation of human gastric adenocarcinoma cell proliferation and direrentiation. |
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