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Differential neurotrophin levels in cerebrospinal fluid and their changes during development in newborn rat |
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| Authors: | Xia Y X Ikeda T Xia X Y Ikenoue T |
| Institution: | Department of Obstetrics and Gynaecology, Miyazaki Medical College, 5200 Kihara, Kiyotake-Cho, Miyazaki 889-16, Japan |
| Abstract: | Cerebrospinal fluid concentration of nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), and neurotrophin-3 (NT-3) was measured in normal developing rat from birth to postnatal day (PND) 21 by enzyme-linked immunosorbent assay. NGF levels were significantly higher than those of BDNF and NT-3 from PND 1–21. NGF levels decreased from PND 1–3 to PND 9. At PND 15 and 17, NGF levels peaked a second time and rapidly decreased to PND 21. BDNF peaked at PND 13–15, while NT-3 levels peaked at PND 7–9. Each of the three neurotrophins has its own characteristic pattern in changes in cerebrospinal fluid levels. |
| Keywords: | Nerve growth factor Brain-derived neurotrophic factor Neurotrophin-3 Cerebrospinal fluid Newborn rat Enzyme-linked immunosorbent assay |
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