A comparative controlled trial of intralesionally-administered zinc sulphate, hypertonic sodium chloride and pentavalent antimony compound against acute cutaneous leishmaniasis |
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| Authors: | K.E. SHARQUIE R.A. NAJIM I.B. FARJOU |
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| Affiliation: | Department of Dermatology.;Department of Pharmacology, College of Medicine, University of Baghdad, P.O. Box 14321. Postal code 12112, Baghdad, Iraq |
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| Abstract: | A comparative clinical trial between two newly introduced intralesional treatments for acute leishmaniasis and the established treatment of intralesionally-administered pentavalent antimony compounds was performed. Treatments were allocated randomly to a total of 63 patients who received 2% zinc sulphate, 7% sodium chloride solutions or sodium stibogluconate intralesionally. A number of patients were left without treatment as controls. Patients were followed-up for 45 days, the results showing that the three treatments gave comparable cure rates by the end of the follow-up period. However, zinc sulphate gave a high cure rate (94.8%) usually with a single injection. |
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