奈达铂化疗同步放疗治疗局部晚期鼻咽癌45例

[目的]探讨奈达铂化疗同步放疗治疗局部晚期鼻咽癌的疗效和不良反应。[方法]84例局部晚期鼻咽癌患者,随机分为奈达铂组（45例）和顺铂组（39例）,两组在根治性放疗的同时给予奈达铂（奈达铂100mg/m^2静滴d1、22、43）或顺铂（顺铂100mg/m^2,静滴d1、22、43）化疗。[结果]奈达铂组CR42例（93.3%）,PR3例（6.7%）,顺铂组CR35例（89.7%）,PR4例（10.3%）,两组疗效差异无显著性（P〉0.05）。奈达铂组和顺铂组胃肠道反应发生率分别为22.2%和46.2%,差异有显著性（P〈0.05）,两组骨髓抑制、肝、肾功能损害、皮肤黏膜反应发生率差异均无统计学意义（P〉0.05）。[结论]奈达铂化疗同步放疗治疗局部晚期鼻咽癌疗效确切,不良反应可耐受。

Nedaplatin Chemotherapy with Concurrent Radiotherapy in the Treatment for 45 Cases with Locally Advanced Nasopharyngeal Carcinoma

[Purpose] To investigate the response and side effect of nedaplatin(NDP) chemotherapy with concurrent radiotherapy for patients with locally advanced nasopharyngeal carcinoma.[Methods] Ninety-four cases with locally advanced nasopharyngeal carcinoma were randomized divided into the NDP group(n=45) and DDP group(n=39).All patients received radical radiation with concurrent NDP(NDP 100mg/m2,intravenous,d1,22,43) or DDP(DDP 100mg/m2,intravenous,d1,22,43) chemotherapy.[Results] In NDP group,CR was 42 cases(93.3...