CADASIL in Arabs: clinical and genetic findings |
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| Authors: | Saeed Bohlega Asmahan Al Shubili Abdulrahman Edris Abdulrahman Alreshaid Thamer AlKhairallah M Walid AlSous Samir Farah Khaled K Abu-Amero |
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| Affiliation: | (1) Department of Neurosciences, King Faisal Specialist Hospital & Research Centre, Riyadh, Saudi Arabia;(2) Neurology Department, Ibn Sina Hospital, Kuwait;(3) Hera Hospital, Mecca, Saudi Arabia;(4) Islamic Hospital, Amman, Jordan;(5) Department of Genetics, King Faisal Specialist Hospital & Research Centre, Riyadh, Saudi Arabia |
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| Abstract: | Background Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is increasingly recognized as an inherited arterial disease leading to a step-wise decline and eventually to dementia. CADASIL is caused by mutations in NOTCH3 epidermal growth factor-like repeat that maps to chromosome 19. CADASIL cases have been identified in most countries of Western and Central Europe, the Americas, Japan, Australia, the Caribbean, South America, Tanzania, Turkey, South Africa and Southeast Asia, but not in Arabs. |
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