| 大肠癌CXCR4表达及其与预后的关系 |
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| 引用本文： | 李权,杨银龙,张筱骅,杨开颜,万丽. 大肠癌CXCR4表达及其与预后的关系[J]. 肿瘤学杂志, 2011, 17(6): 454-456 |
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| 作者姓名： | 李权 杨银龙 张筱骅 杨开颜 万丽 |
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| 作者单位： | 温州医学院附属第一医院,浙江,温州,325000 |
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| 摘 要： | [目的]探讨CXCR4在大肠癌中的表达情况及其与预后的关系。[方法]采用SP免疫组化方法检测70例大肠癌组织和14例癌旁组织中CXCR4蛋白的表达。[结果]CXCR4蛋白在大肠癌组织中阳性表达率为57.1%（40/70）,显著高于癌旁组织的14.3%（2/14）（P〈0.01）。CXCR4阳性表达与大肠癌的Duke分期（P=0.041）、淋巴结转移（P=0.018）显著相关。CXCR4阴性表达者的无瘤生存率显著优于阳性表达者（P=0.008）。[结论]CXCR4蛋白在大肠癌中过度表达与大肠癌的发生发展和预后相关。
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| 关 键 词： | 大肠肿瘤 CXCR4 免疫组化 预后 |
Expression of CXCR4 and its Relationship with Prognosis of Colorectal Cancer |
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| LI Quan,YANG Yin-long,ZHANG Xiao-hua,et al.. Expression of CXCR4 and its Relationship with Prognosis of Colorectal Cancer[J]. Journal of Chinese Oncology, 2011, 17(6): 454-456 |
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| Authors: | LI Quan YANG Yin-long ZHANG Xiao-hua et al. |
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| Affiliation: | LI Quan,YANG Yin-long,ZHANG Xiao-hua,et al.(The First Affiliated Hospital of Wenzhou Medical College,Wenzhou 325000,China) |
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| Abstract: | [Purpose] To investigate expression of CXCR4 and its relationship with prognosis of colorectal cancer.[Methods] The expression of CXCR4 in 70 cases with colorectal cancer tissue and 14 cases with cancer adjacent tissue was detected by immunohistochemistry.[Results] The positive rate of CXCR4 in colorectal cancer(57.1%,40/70) was significantly higher than that in cancer adjacent tissue(14.3%,2/14)(P<0.01).The positive expression of CXCR4 was related to Dukes' stage(P=0.041) and lymph node metastasis(P=0.018)... |
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| Keywords: | colorectal neoplasms CXCR4 immunohistochemistry prognosis |
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