| 索拉非尼联合表阿霉素对乳腺癌MCF-7细胞的增殖抑制作用 |
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| 引用本文： | 胡燕,姚颐,吴冰,马广栋,王陆洲,李承军. 索拉非尼联合表阿霉素对乳腺癌MCF-7细胞的增殖抑制作用[J]. 肿瘤学杂志, 2011, 17(7): 521-523 |
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| 作者姓名： | 胡燕 姚颐 吴冰 马广栋 王陆洲 李承军 |
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| 作者单位： | 武汉大学人民医院肿瘤中心,湖北 武汉,430060 |
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| 摘 要： | [目的]探讨索拉非尼联合表阿霉素对乳腺癌MCF-7细胞的增殖抑制作用。[方法]绘制MCF-7细胞生长曲线并在第14d检测其体外克隆形成率;MTT法测定72h时索拉非尼及表阿霉素单用与联用对MCF-7细胞的增殖抑制率。[结果]细胞生长曲线显示MCF-7细胞第1-4d生长速度较快,第4d后生长速度减慢,第10d后生长趋于停滞;第14dMCF-7细胞的克隆形成率为37.2%。在72h时间点,索拉非尼及表阿霉素单药对MCF-7均有抑制作用,两药联合则为协同或相加作用。[结论]索拉非尼和表阿霉素对乳腺癌MCF-7细胞增殖有抑制作用,联合用药表现出协同或相加作用。
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| 关 键 词： | 乳腺肿瘤 索拉非尼 表阿霉素 MCF-7细胞 增殖抑制 |
The Inhibitory Effect of Sorafenib Combined with Epirubicin on Proliferation in Breast Cancer MCF-7 Cells |
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| HU Yan,YAO Yi,WU Bing,et al.. The Inhibitory Effect of Sorafenib Combined with Epirubicin on Proliferation in Breast Cancer MCF-7 Cells[J]. Journal of Chinese Oncology, 2011, 17(7): 521-523 |
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| Authors: | HU Yan YAO Yi WU Bing et al. |
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| Affiliation: | HU Yan,YAO Yi,WU Bing,et al. (Renmin Hospital of Wuhan University,Wuhan 430060,China) |
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| Abstract: | [Purpose] To investigate the inhibitory effect of sorafenib combined with epirubicin (EPI) on the proliferation in breast cancer MCF-7 cells. [Methods] The growth curve of MCF-7 cells and cloning efficiency on 14th day was detected. The inhibitory effect of sorafenib,EPI and sorafenib+EPI treatment on MCF-7 proliferation in vitro was assessed by MTT assay at 72h. [Results] The growth curve showed that the growth velocity of MCF-7 cells was fast at the 1st~4th day,but slowed down after the 4th day,and stayed... |
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| Keywords: | breast neoplasms sorafenib epirubicin MCF-7 cell proliferation |
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