Suramin: a reversible P2-purinoceptor antagonist in the mouse vas deferens. |
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| Authors: | P. M. Dunn and A. G. Blakeley |
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| Affiliation: | Department of Physiology, University of Leicester. |
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| Abstract: | The trypanocide Suramin was tested as a possible antagonist at the P2-purinoceptor of the mouse vas deferens. At a concentration of 100 microM, Suramin antagonized the response to alpha,beta-methylene ATP, while responses to carbachol and noradrenaline were unaffected. These results suggest that Suramin may provide a starting point for the development of specific antagonists for P2-purinoceptors. |
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