β—胡萝卜素对TAⅡ小鼠移植性乳腺癌MA737影响的研究

观察β－胡萝卜素对移植性乳腺癌生长，荷瘤小鼠生存期及对ＣＭＦ化疗毒副作用的影响。方法采用ＴＡⅡ小鼠移植性乳腺癌模型，荷瘤小鼠给予ＢＣ和ＣＭＦ不同处理。结果（１）ＢＣ组、ＢＣ＋ＣＭＦ组平均每只小鼠生存时间较对照组显著延长，ＣＭＦ组小鼠因化疗毒性其生存时间较对照组明显缩短。（２）ＣＭＦ小鼠在实验７天内全部死亡外，ＢＣ组、ＢＣ＋ＣＭＦ组在实验不同时期肿瘤体积均明显小于对照组。（３）长期单独灌喂ＢＣ小鼠均

Effect of beta-carotene on mouse transplantable mammary cancer MA737]

OBJECTIVE: To study the effect of beta-carotene (BC) on the growth of MA737 in TA II mice. METHODS: BC (250 mg/kg) dissolved in vegetable oil was given per os by gavage once every other day. Mice were treated with BC alone or in combination with chemotherapy (CMF protocol). Control mice were given solvent vehicle. Tumor volume and survival period of the treated and control mice were recorded. RESULTS: In mice treated with BC alone, the growth of the tumor was retarded, but the tumor inhibitory effect was more marked in mice treated with BC + CMF (growth inhibition rate: 49.1% versus 60.5%). The therapeutic effect of combined use of BC and CMF was only slightly better than that of CMF alone. However, BC helped alleviate toxic side effects of the chemotherapeutic drugs so that the survival period was significantly prolonged in the BC + CMF treated mice. Long term treatment with beta-carotene was without side effect. CONCLUSION: beta-carotene inhibits tumor growth, prolongs survival and alleviates toxic side effects of chemotherapy in a mouse mammary cancer model.