宫颈癌IB1、IB2期的临床回顾性分析

目的 分析宫颈癌分期中ＩＢ１、ＩＢ２期的治疗结果以及淋巴结转移、宫颈间质浸润、组织分级与预后的关系。方法 ３５６例ＩＢ期宫颈癌全部行广泛性子宫切除和盆脸淋巴清除术，７２例辅以术前放疗（ＩＢ１期３９例，ＩＢ２期３３例），８３例行术后放疗（ＩＢ１期６１例，ＩＢ２期２２列１例行术前，术后放疗（ＩＢ２期５例，ＩＢ２期６例）。结果 随访５年以上者２４９例，总的５年存活率６９．９％，ＩＢ１期为７３．３％（１８

A clinical retrospective review of stage IB 1 and IB 2 cervical cancer

Objective To investigate the prognostic factors and treatment of cervical cancer in stage IB 1 and IB 2. Methods Three hundred fifty six patients with stage IB cervical cancer were treated with redical hysterectomy. Seventy two patients received preoperative radiation (IB 1 n=39, IB 2 n=33), 83 patients received postoperative radiation (IB 1 n=61, IB 2 n=22), 11 patients received radiation before and after operation (IB 1 n=5, IB 2 n=6). Results Two hundred forty nine patients had been followed up for more than 5 years. The overall 5 year survival rate was significantly higher in patients in stage IB 1 than in stage IB 2. In patients with deep tumor invasion of the cervical matrix, the difference in 5 year survival was also significantly different between patients in stage IB 1 and IB 2. However, no significant difference was observed between the 2 groups of patients with positive nodes, nor was it related to tumor cell differentiation. Patients treated with surgery alone had similar 5 year survival rates but it was significantly higher in stage IB 1 than in stage IB 2 patients who received preoperative radiotherapy. Post operative radiotherapy did not help survival in both groups of patients. Conclusion The survival rate of cervical cancer in stage IB 1 significantly differs from that in stage IB 2. However, postoperative radiotherapy does not help improve survival of stage IB 1 and IB 2 patients with high risk factors.