去甲去氢长春碱治疗48例非小细胞肺癌的近期疗效

目的 评价去甲去氢长春碱（诺维本，ＮＶＢ）对非小细胞肺癌（ＮＳＣＬＣ）的治疗作用。方法 采用诺维本为主药的联合方案治疗非小细胞肺癌４８例，均为初治患者，均经细胞学或病理证实。结果 本组４８例中，没有完全缓解病例，部分缓解２０例，有效率为４１．７％，其中腺癌有效率为５３．５％，鳞癌有效率为２５．０％，其差异有显著性。ＮＰ方案：诺维本（ＮＢ）＋顺铂（ＰＤＤ）治疗２０例，有效率为４０．０％，ＮＩ方案；Ｎ

Short term effect of navelbine on non small cell lung cancer in 48 cases

Objective To evaluate effect of navelbine on non small cell lung cancer (NSCLC). Methods Forty eight cases of cytologically and pathologically confirmed advanced NSCLC were treated with combined chemotherapy including navelbine as the cardinal drug from May, 1995 to January, 1988. They were randomly divided into two groups. One group of 20 cases was treated with NP regimen (NVB PDD); the other group of 28 cases was treated with NI regimen (NVB IFO). All patients received no previous treatment. Results There was no complete response in patients treated with either regimen. Partial response was observed in 8 of 20 NP treated patients(40.0%) and in 12 of 28 NI treated patients (42.8%). There was no statistical difference in response rate between these 2 groups of NSCLC patients, However, in both groups of patients, the therapeutic effect was better in adenocarcinoma than in sequamous cell carcinoma patients. NP regimen seemed effective in the control of bone metastases and pains. Side effects were mainly myelo suppression and digestive tract reaction. Conclusion Combined chemotherapy including NVB is worthy of use in the treatment of advanced NSCLC especially for those with bone metastasis.