| 肝性脑病患者血氨、血清色氨酸、5-羟色胺及5-羟吲哚乙酸的测定 |
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| 引用本文： | 易世林,徐葆元. 肝性脑病患者血氨、血清色氨酸、5-羟色胺及5-羟吲哚乙酸的测定[J]. 重庆医科大学学报, 1989, 0(4) |
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| 作者姓名： | 易世林 徐葆元 |
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| 摘 要： | 血氨浓度、血清游离色氨酸浓度及游/总色氨酸比值在肝性脑病患者明显高于失代偿性肝硬化、原发性肝癌与亚急性重症肝炎(P<0.01)。在肝性脑病患者血清5-羟色胺浓度增高不显著,但血清5-羟吲哚乙酸浓度明显高于正常对照(P<0.01)。血清游离色氨酸浓度及游/总比值与肝性昏迷的分级呈密切正相关。血氨浓度与肝性昏迷分级无相关性。文章对氨代谢和色氨酸代谢紊乱在肝性脑病发生机理中的重要作用进行了讨论
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| 关 键 词： | 肝性脑病 血氨 色氨酸 5-羟色胺 5-羟吲哚乙酸 |
DETERMINATION AND CLINICAL SIGNIFICANCE OF CONCENTRATIONS OF PLASMA AMMONIA, SERUM TRYPTOPHAN, SEROTONIN AND 5-HYDROXYINDOLACETIC ACID IN PATIENTS WITH HEPATIC ENCEPHALOPATHY |
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| Abstract: | Our study showed that the concentration of plasma ammonia in patients with hepatic encephalopathy was increased significantly than that in patients with decompensated liver cirrhosis, primary hepatocellular carcinoma and fulminant hepatitis. The concentration of serum free tryptophan and "free/total" tryptophan ratio in patients with hepatic encepha-lopathy were significantly increased as compared with patients of other three groups. The concentration of serum serotonin was not significantly increased and that of serum 5-hy- droxyindolacetic acid was significantly increased in comparison with normal controls. In addition, the concentrations of serum free tryptophan and serum "free/total" ratio were closely positive correlated with the degree of hepatic encephalopathy, the concentrations of. plasma ammonia and serum free tryptophan and serum "free/total" ratio were higher in patients with hepatic coma than that of patients regainning consciousness, but the difference was not statistically significant. The role of plasma ammonia and serum tryptophan in pathogenesis of hepatic encephalopathy was discussed |
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| Keywords: | hepatic encephalopathy ammonia tryptophan serotonin 5-hydroxyin-dolacetic acid |
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