结缔组织生长因子与糖尿病肾病

糖尿病肾病目前尚缺乏早期诊断的有效方法,且治疗效果不佳。结缔组织生长因子作为一种致纤维化因子,在糖尿病肾病时的肾脏系膜细胞、足细胞、肾间质细胞中表达增加,并反作用于上述细胞。其机制可能是结缔组织生长因子与细胞表面硫酸类肝素蛋白多糖、酪氨酸激酶受体等结合,诱导细胞炎性反应及基质胶原蛋白合成与纤维粘连蛋白合成,肾脏发生纤维化。结缔组织生长因子是肾脏纤维化与蛋白尿形成的一种因素,特异性阻断结缔组织生长因子可能会成为治疗糖尿病肾病的新方向。

Connective Tissue Growth Factor and Diabetic Kidney Disease

There is a lack of effective method for early diagnosis of diabetic kidney disease,and the treatment outcomes are not acceptable.As a fibrogenic factor,connective tissue growth factor is increased in mesangial cells,podocytes and interstitial cells in diabetic kidney disease,and vice versa.The mechanisms may be including connective tissue growth factor induced the inflammatory response,matrix collagen and fibronectin synthesis by binding with heparan sulfate proteoglycans and receptor tyrosine kinase.Connective tissue growth factor is one of the factors resulting in renal fibrosis and proteinuria.Therefore,specific blockade of connective tissue growth factor expression and synthesis may be a new approach to treat diabetic kidney disease.