Epidemiological study of phylogenetic transmission clusters in a local HIV-1 epidemic reveals distinct differences between subtype B and non-B infections |
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| Authors: | Kristen Chalmet Delfien Staelens Stijn Blot Sylvie Dinakis Jolanda Pelgrom Jean Plum Dirk Vogelaers Linos Vandekerckhove Chris Verhofstede |
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| Affiliation: | (1) AIDS Reference Laboratory, Ghent University, De Pintelaan 185-Blok A, B-9000 Gent, Belgium;(2) AIDS Reference Center, Ghent University Hospital, De Pintelaan 185-1P2, B-9000 Gent, Belgium |
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| Abstract: | Background The number of HIV-1 infected individuals in the Western world continues to rise. More in-depth understanding of regional HIV-1 epidemics is necessary for the optimal design and adequate use of future prevention strategies. The use of a combination of phylogenetic analysis of HIV sequences, with data on patients' demographics, infection route, clinical information and laboratory results, will allow a better characterization of individuals responsible for local transmission. |
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