| 药物分子设计的策略:药理活性与成药性 |
| |
| 作者姓名： | Guo ZR |
| |
| 作者单位： | 中国医学科学院药物研究所; |
| |
| 摘 要： | 化合物的内在活性和成药性是创新药物的两个基本要素,活性是药物的基础和核心,成药性是辅佐活性发挥药效的必要条件,两者互为依存。药物在体内的药剂相、药代动力相和药效相可概括为活性和成药性的展示过程。成药性是药物除活性外的其他所有性质,包括物理化学性质、生物化学性质、药代动力学性质和毒副作用,这是在不同层次上表征药物的性质和行为,但又相互关联与制约。活性与成药性由化学结构所决定,体现在微观结构与宏观性质的结合上,寓于分子的结构之中。先导物的优化是对活性、物化、生化、药代和安全性等性质的多维空间的分子操作,因而具有丰富的药物化学内涵。
|
| 关 键 词： | 分子设计 内在活性 成药性 先导物优化 |
Strategy of molecular drug design: activity and druggability |
| |
| Guo ZR.Strategy of molecular drug design: activity and druggability[J].Acta Pharmaceutica Sinica,2010,45(5):539-547. |
| |
| Authors: | Guo Zong-Ru |
| |
| Institution: | GUO Zong-ru (Institute of Materia Medica,Chinese Academy of Medical Sciences,Beijing 100050,China) |
| |
| Abstract: | Intrinsic activity and druggability represent two essences of innovative drugs.Activity is the fundamental and core virtue of a drug,whereas druggability is essential to translate activity to therapeutic usefulness.Activity and druggability are interconnected natures residing in molecular structure.The pharma-ceutical,pharmacokinetic and pharmacodynamic phases in vivo can be conceived as an overall exhibition of activity and druggability.Druggability actually involves all properties,except for intrinsic act... |
| |
| Keywords: | drug design intrinsic activity druggability lead optimization |
| 本文献已被 CNKI PubMed 等数据库收录！ |
|
