HP相关性溃疡病胃酸分泌功能的研究

目的：探讨幽门螺旋杆菌（HP）感染对溃疡病胃酸分泌功能的影响。方法：对19例HP阳性的溃疡病患者于治疗前后进行了胃镜、HP、空腹血清鲁泌素（GAS）及五肽胃泌素胃液分析。并与10例HP阴性溃疡病的结果对比。结果：HP相关性溃疡HP清除前空腹血清GAS，基础胃酸分泌量（BAO）、最大胃酸分泌量（MAO）、高峰胃酸分泌量（PAO）均明显提高，清除HP后均明显降低。而HP阴性溃疡组GAS治疗前后无明显差异，BAO、MAO及PAO治疗前虽亦高于正常，治疗后亦有降低，但均无HP阳性组显著，有统计学意义。提示HP感染可使GAS及胃酸分泌增加，可能是HP相关性溃疡的重要病因之一。

The Investigation of Gastric Acid Secreation of Peptic Ulcer Patients Associated with Helicobacter Pylori

To investigate the effect of HP on the gastric acid secreation in peptic ulcer (PU) associated with helicobacter pylori (HP). Methods: H.Pylori status was determinated by urease and histology. Endoscopy:Pentagastrin gastric juice analysis and concentration fasting blood gastrin (GAS) were measured before and after treatment in l9 cases of peptic ulcer with HP infection,10 of peptic ulcer patients without were studied as control. Conclusion: The concentration of GAS,basal acid output (BAO), maximal acid output (MAO) and peak acid output (PAO) in PU with HP infection was all significantly hlgher than that without HP infection. They decreased obviously after HP clearance. In PU without HP,the concentration was found no difference between before and after treatment.Although the BAO,MAO and PAO were higher than those of normal persons and decreased after treatment,the change was not significantly more than that of the HP positive group. It's suggested that HP infection induced increase of gastric acid secreation and concentration of GAS.It may be one of pathogenesis PU associated wit HP.