| ^32磷玻璃微球组织内照射对肿瘤细胞凋亡影响的实验研究 |
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| 引用本文： | 汪永跃王大章,郑光勇. ^32磷玻璃微球组织内照射对肿瘤细胞凋亡影响的实验研究[J]. 华西口腔医学杂志, 2001, 19(2): 116-117 |
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| 作者姓名： | 汪永跃王大章 郑光勇 |
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| 作者单位： | 汪永跃（610041 四川大学华西口腔医学院颌面外科学教研室）;王大章（610041 四川大学华西口腔医学院颌面外科学教研室）;郑光勇（610041 四川大学华西口腔医学院颌面外科学教研室） |
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| 摘 要： | 目的观察
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| 关 键 词： | 细胞凋亡 组织内照射 ^32磷玻璃微球 肿瘤 放射治疗 |
| 修稿时间： | 2000-11-27 |
Impact of interstitial irradiation with 32P glass microspheres on cellular apoptosis of mice with the solid tumor S180] |
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| Wang Yongyue. Impact of interstitial irradiation with 32P glass microspheres on cellular apoptosis of mice with the solid tumor S180][J]. West China journal of stomatology, 2001, 19(2): 116-117 |
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| Authors: | Wang Yongyue |
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| Affiliation: | Department of Oral Maxillofacial Surgery, College of Stomatology, West China University of Medical Sciences. |
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| Abstract: | OBJECTIVE: The aim of this study is to observe apoptotic changes of tumor cells in mice with the solid tumor S180 after interstitial irradiation with 32P glass microspheres. METHODS: Twenty mice with solid tumor S180 were divided into four groups. The control group was given normal saline. The experimental groups were given different doses of 32P glass microspheres (50, 150, 450uci per mouse) using interstitial implant. The terminal deoxynucleotidyl transferase mediated dUTP nick end labeling (TUNEL) method was used to determine the apoptotic cells. RESULTS: The mean values of the apoptotic indexes of these groups were respectively 0.39, 0.41, 0.59 and 0.95. The apoptotic indexes of the second and the third experimental groups were significantly higher than that of the control group (P < 0.05). CONCLUSION: The interstitial irradiation with 32P glass microspheres can enhance the activity of apoptotic cells of solid tumor S180, and the effect is dose-dependent. |
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