甘糖酯的抗血栓作用及其作用机理

本文研究了硫酸甘糖酯(PGMS)对家兔实验性血栓形成及急性实验性肺动脉血栓栓塞的影响,并与等抗凝效价肝素进行了比较。结果提示,PGMS具有较好的抗血栓作用。为探讨其作用机理,还观察了PGMS对家兔凝血系统和纤维蛋白溶解系统的影响。研究结果提示,PGMS可通过抑制凝血系统和激活纤维蛋白溶解系统而发挥其抗血栓作用。

THE STUDY OF ANTITHROMBOTIC EFFECT AND MECHANISM OF PROPYLENE GLYCOL MANNATE SUFATE

The influences of propylene glycol mannate sulfate (PGMS) on experimental thrombosis and thrombolysis in vivo were studies after iv 8. 125, 6. 25, 12. 5 , 25mg/Kg in rabbits, and the effect of antithrombosis of PGMS was compared with that of heparin. The results showed that PGMS possessed remarkable effect of antithrombosis. In order to explore the mechanism of antithrombosis of PGMS, we studied the influences on the fibrinolytic and coagulant function of rabbits. The results showed that PGMS can pronouncedly prolong the prothrombin time (PT), thrombin time (TT), kaolin partial thromboplastin time (KPTT), and enhance the activity of antithrombin-III (AT -III). PGMS can cause a remarkable increase in fibrin degradation product (FDP) , shorten euglobulin lysis time (ELT) , and a decrease in the contents of fibrinogen and plasminogen activity. These results suggested that PGMS probably exert the antithrombotic effect by inhibiting coagulation and activating fibrinolysis.