内皮素、N末端脑钠肽水平与急性心肌梗死患者预后的相关性研究

目的探讨急性心肌梗死患者血清内皮素(ET)及N末端脑钠肽(NT-proBNP)的表达及与患者预后的相关性。方法选择120例急性心肌梗死患者为研究对象,检测患者血清ET及NT-proBNP水平,探讨二者与冠状动脉病变、心功能分级及心血管事件发生率的关系。结果冠脉2支以上病变者血清ET及NT-proBNP水平显著高于单支病变者(P<0.05);随着心功能分级的升高,患者血清ET及NT-proBNP水平依次升高(P<0.05);发生心血管事件患者血清ET及NT-proBNP水平显著高于未发生心血管事件者(P<0.05)。结论 ET及NT-proBNP参与急性心肌梗死的发病机制,可作为评估患者病情严重程度及预后的指标。

Correlation of ET and NT - proBNP with prognosis in acute myocardial infarction patients

Objective To explore the correlation of ET and NT-proBNP with prognosis in acute myocardial infarction patients.Methods 120 cases with acute myocardial infarction were selected as research subjects.Serum ET and NT-proBNP were detected in the patients and their relationship with coronary artery disease,cardiac function classification and the cardiovascular events were studied.Results Serum ET and NT-proBNP in multi-vessels disease patients were much higher than those in single vessels disease（P 0.05）.With the increasing of cardiac function classification,serum ET and NT-proBNP gradually increased（P 0.05）.ET and NT-proBNP level were much higher in patients with cardiovascular events than those in patients without cardiovascular events（P 0.05）.Conclusion ET and NT-proBNP participate in the pathogenesis of acute myocardial infarction patients.These indexes can be considered as the evaluation indexes for the disease severity.