乌司他丁联合无创正压通气治疗48例急性肺损伤患者血气指标分析及临床疗效比较

目的研究乌司他丁联合无创正压通气(NIPPV)治疗急性肺损伤(ALI)患者血气指标及临床疗效。方法选择ALI患者作为研究对象,随机分为观察组(给予乌司他丁联合NIPPV治疗)和对照组(乌司他丁联合气管插管、呼吸机辅助呼吸治疗),观察两组血气和药代动力学指标。结果观察组动脉血氧分压(PaO2)、氧和指数(PaO2/FiO2)、pH值、乌司他丁浓度峰值均明显高于对照组,动脉血二氧化碳分压(PaCO2)达到峰值的时间和半衰期明显低于对照组。结论乌司他丁联合NIPPV治疗ALI患者能够有效的改善血气指标、保证血药浓度,具有积极的临床价值。

A comparative study on blood gas analysis and clinical effect of ulinastatin combined with NIPPV in treatment of 48 patients with acute lung injury

Objective To study the changes in blood gas and clinical effect of ulinastatin combined with NIPPV in treatment of 48 patients with acute lung injury（ALI）.Methods Patients with acute lung injury were collected and randomly divided into observation group and control group,patients in observation group were given with ulinastatin and NIPPV and patients in control group were given with NIPPV.Then blood gas analysis and index of pharmacokinetics were observed.Results PaO2,PaO2/ FiO2,pH value and CMAX in patients of observation group were significantly higher than those of patients in control group,PaCO2,TMAX and T1/2 were significantly lower than those of control group.Conclusion The effect of ulinastatin combined with NIPPV has positive clinical significance in treatment of patients with acute lung injury.It can improve the index of blood gas and ensure the blood concentration of drugs.