血清前白蛋白和总胆汁酸在诊断肝硬化分级中的价值

目的探讨血清前白蛋白(PA)和总胆汁酸(TBA)在诊断肝硬化分级中的意义。方法试验组由96例肝硬化患者组成,对照组由95例健康体检者组成。分别检测试验组(按肝硬化Child-Pugh分级,A、B、C三级分别为30例、33例、33例)和对照组血清中血清前白蛋白(PA)与总胆汁酸(TBA)水平,采用统计软件对结果进行处理。结果试验组血清前白蛋白水平明显低于对照组,有显著统计学差异(P﹤0.01),且A、B、C三级之间比较有统计学差异;试验组总胆汁酸水平明显高于对照组比较,差异性明显(P﹤0.05),且A、B、C三级之间比较,有显著性差异(P﹤0.01)。结论血清前白蛋白、总胆汁酸能较准确地反映出肝硬化的程度,敏感地判断肝硬化等级。

The value of serum prealbumin and total bile acid in the diagnosis of liver cirrhosis classification

Objective To investigate the significance of serum prealbumin（PA） and total bile acid（TBA） in the diagnosis of liver cirrhosis grading.Methods Ninety-six cases of liver cirrhosis（Child-Pugh grade A,B and C were 30,33,and 33,respectively） were selected as the experimental group,65 healthy persons were served as control group.Serum PA and TBA were detected and their levels were compared between two groups.Results Serum PA was significantly lower in experimental group than control group（P 0.01）,and significant difference in the serum PA level was found among Child-Pugh grade A,B and C patients.TBA level in experimental group was significantly higher than control group（P 0.05）,and significant difference in TBA level was found among Child-Pugh grade A,B and C patients（P 0.01）.Conclusion Serum PA and TBA can accurately reflect the severity of hepatic cirrhosis and facilitate the determination of liver cirrhosis grade.