重型颅脑损伤急行双侧去大骨瓣减压术后立即应用尼莫地平的临床疗效观察

目的通过实验对比观察分析重型颅脑损伤急行双侧去大骨瓣减压术后立即应用尼莫地平的临床作用效果。方法 128重型颅脑损伤急性双侧去大骨瓣减压术后患者随机分成两组,照组患者进行术后常规治疗,实验组患者术后进行常规治疗的同时立即应用尼莫地平。观察比较两组的临床疗效。结果两组患者的治疗方法均有明显效果(P<0.05),但是两组差异无显著性(P>0.05)。实验组治疗后1个月及治疗后6个月的简易精神状态检查(MMSE)评分均高于对照组(P<0.05)。结论重型颅脑损伤急行双侧去大骨瓣减压术后立即应用尼莫地平能够明显提高患者的术后疗效,有助于患者的精神状态恢复。建议去大骨瓣减压术后立即应用尼莫地平。

Study on clinical effect of nimodipine in treatment of severe craniocerebral injury after bilateral decompressive craniectomy

Objectives To observe and analyze clinical effect of nimodipine in treatment of severe craniocerebral injury after bilateral decompressive craniectomy.Methods A total of 128 patients with severe craniocerebral injury performed bilateral decompressive craniectomy in this hospital were selected for this study,they were randomly divided into experimental group and control group,patients in control group were proceeded with postoperative routine treatment,while patients in experimental group were additionally given with nimodipine on the basis of routine treatment.The clinical effects had been observed and compared between these two groups.Results Both these two treatment methods had significant curative effects in patients（P 0.05）,and there was no obvious difference between these two groups（P 0.05）,but the mini-mental state examination scores of patients in experimental group were higher than those of patients in control group after treatment for one to six months（P 0.05）,and the difference had statistical meaning.Conclusion The application of nimodipine to patients with severe craniocerebral injury after bilateral decompressive craniectomy can evidently improve their postoperative curative effect,and it is beneficial to the recovery of mental state of patients.Therefore,it has been suggested to apply nimodipine immediately to patients after decompressive craniectomy.