Afferent stimulation frequency modulates GABAergic phenomena in the spinal cord: reversal by benzodiazepine antagonists |
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| Authors: | P Polc I Duci? |
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| Institution: | Pharma Research Department, F. Hoffmann-La Roche Ltd., Basel, Switzerland. |
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| Abstract: | Switching from a low (0.5 Hz) to a higher (5 Hz) frequency repetitive stimulation of hindlimb muscle nerve afferents reduced GABA-mediated dorsal root potentials and dorsal root reflexes in the lumbosacral cord of spinal cats. Benzodiazepine receptor antagonists flumazenil and Ro 15-3505 in a very low dose (0.03 mg/kg i.v.) reversed this effect suggesting a stimulation-coupled release of an endogenous benzodiazepine receptor ligand down-regulating GABAA-receptors in the spinal cord. |
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