Inhibitory effects of bacterial endotoxin and reserpine on the uptake of 3H-5-hydroxytryptamine by granule fractions of blood platelets |
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| Authors: | I Kuruma T Okada H Takagi |
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| Affiliation: | Department of Pharmacology, Faculty of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan |
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| Abstract: | In rabbit platelets, bacterial endotoxin (lipopolysaccharide), at a concentration of 10−4 g/ml, inhibited the uptake of 3H-5HT by platelets, especially by the granule fraction. Reserpine, at a concentration of 10−7 g/ml, counteracted the uptake of 3H-5HT by platelets, especially by the granule fraction. |
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| Keywords: | Blood platelets Bacterial endotoxin Reserpine 5-Hydroxytryptamine, uptake and upkeep Lipopolysaccharide |
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