| MDR1基因多态性对妇科患者芬太尼静脉镇痛药效学的影响 |
| |
| 引用本文： | 张卫,赵二贤,阚全程,常琰子,张莉蓉,王中玉,袁静静. MDR1基因多态性对妇科患者芬太尼静脉镇痛药效学的影响[J]. 中国药学杂志, 2010, 45(5): 379-380 |
| |
| 作者姓名： | 张卫 赵二贤 阚全程 常琰子 张莉蓉 王中玉 袁静静 |
| |
| 作者单位： | 郑州大学第一附属医院麻醉科;郑州大学第一附属医院临床药理基地;河南省高等学校临床医学重点学科开放实验室;郑州大学基础医学院药理学教研室; |
| |
| 基金项目： | 河南省医学科技攻关项目(200703018) |
| |
| 摘 要： | 目的 观察MDR1C3435T多态性对妇科患者芬太尼静脉镇痛效应的影响。方法 196例全麻下行妇科择期手术的患者，手术结束患者清醒后行芬太尼患者自控静脉镇痛（PCIA）。记录患者自控静脉镇痛24 h内芬太尼用量。采用聚合酶链反应-限制性片断长度多态性（PCR-RFLP）技术检测MDR1C3435T多态性。结果 196例患者中，CC型 82例，CT型86例，TT 型28例。MDR1C3435T的突变频率为36.2%。术后24 h内3组间芬太尼消耗量差异无统计学意义。结论 MDR1C3435T多态性不是引起芬太尼药效学差异的遗传因素。
|
| 关 键 词： | 基因多态性 芬太尼 镇痛药效学 |
| 收稿时间： | 2012-01-01; |
Genetic Polymorphisms in the MDR1 Gene and Effects on Analgesia Pharmacodynamic of Fentanyl |
| |
| ZHANG Weia,ZHAO Er-xiana,KAN Quan-chengb,,CHANG Yan-zia,ZHANG Li-rong,WANG Zhong-yua,YUAN Jing-jinga. Genetic Polymorphisms in the MDR1 Gene and Effects on Analgesia Pharmacodynamic of Fentanyl[J]. Chinese Pharmaceutical Journal, 2010, 45(5): 379-380 |
| |
| Authors: | ZHANG Weia ZHAO Er-xiana KAN Quan-chengb CHANG Yan-zia ZHANG Li-rong WANG Zhong-yua YUAN Jing-jinga |
| |
| Affiliation: | ZHANG Wei1a,ZHAO Er-xian1a,KAN Quan-cheng1b,2,CHANG Yan-zi1a,ZHANG Li-rong3,WANG Zhong-yu1a,YUAN Jing-jing1a(1.First Affiliated Hospital,Zhengzhou University,a.Department of Anesthesiology,b.Clinical Pharmacology Base,Zhengzhou 450052,China,2.Open Key Clinical Medical Laboratory Institute of Henan Province,3.School of Basic Medical Pharmacology Teaching , Research Section,China) |
| |
| Abstract: | OBJECTIVE To evaluate the impact of MDR1C3435T genetic polymorphism on the analgesic effect of fentanyl.METHODS One hundred and ninety-six patients scheduled for elective Gynecologic surgery undergoing general anesthesia were enrolled in this study.Fentanyl PCIA was then performed after the patients came to consciousness.The amount of fentanyl used within 24 h during PCIA was recorded.The polymorphic sites of MDR1C3435T allele were analyzed by polymerase chain reaction-restiction fragment length polymorphis... |
| |
| Keywords: | genetic polymorphisms fentanyl analgesia pharmacodynamic |
| 本文献已被 CNKI 等数据库收录！ |
| 点击此处可从《中国药学杂志》浏览原始摘要信息 |
|
点击此处可从《中国药学杂志》下载免费的PDF全文 |
|
