慢性肺心病急性发作期血清sIL-2R、C_3及CIC水平的检测及其临床意义

目的 :探讨慢性肺心病急性发作期血清中可溶性白细胞介素— 2受体 ( s IL-2 R)及补体 3成分 ( C3)、循环免疫复合物 ( CIC)水平及其临床意义。方法 :采用双抗体夹心 ELISA法 ,单向免疫扩散法、PEC—紫外分光法对慢性肺心病患者血清 s IL-2 R、C3及 CIC进行检测 ,并以直线相关法分析与 Pa O2 、 Pa CO2 的相关性。结果 :肺心病急性发作期患者血清 s IL-2 R、 CIC水平显著高于缓解期及正常对照组 ( P<0 .0 1 ) ,与 Pa O2 呈负相关 ( P<0 .0 5) ,与 Pa CO2 呈正相关 ( P<0 .0 1 ) ,而 C3低于缓解期及对照组。结论 :慢性肺心病患者血清 s IL-2 R、 CIC增高 ,C3下降 ,提示患者体内存在免疫功能紊乱 ,因此 s IL-2 R、C3及 CIC可作为临床观察慢性肺心病患者细胞免疫功能及病情判定的指标

Determination of serum sIL-2R,C_3 and CIC in patients with chronic cor pulmonale and their clinical significance.

Objective:To determine the serum levels of sIL 2R,C 3 and CIC in patients with chronic cor pulmonale and evaluate the clinical significances.Methods:Serum sIL 2R,C 3 anc CIC were detemined by ELISA,single immunodiffuse test and PEG ultraviolet spectroscope in three group of patients. The relationship between PO 2,PaCO 2 and sIL 2R,C 3,CIC were also studied.Results:The levels of sIL 2R and CIC in acute stage were higer than those of remission stage and normal controls ( P <0 01),and the levels of C 3 were lower than those of remission stage.In addition both sIL 2R and CIC were negatively correlated with PaO 2 ( P <0 05).Conclusion:The changes of serum sIL 2R,C 3 and CIC levels suggest that immuno disorder may exist in patients with chronic cor pulmonale and these parmeter may be useful in evaluathing the immuno function of chronic cor pulmonale patient.