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Early imaging in heart failure: Exploring novel molecular targets |
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| Authors: | Jamshid Shirani Jagat Narula William C. Eckelman Navneet Narula Vasken Dilsizian |
| Affiliation: | (1) Geisinger Medical Center, Danville, Pa;(2) School of Medicine, University of California, Irvine, Irvine, 101 The City Drive, Bldg 53, Mail Route 81, 92868-4080 Orange, CA;(3) University of California, San Diego, Calif;(4) Molecular Tracers, Bethesda, Md;(5) University of Maryland Medical Center, Baltimore, Md |
| Abstract: | Conclusions Noninvasive imaging of neurohumoral upregulation in remodeled myocardium suggests that an imaging strategy can be developed for predicting the rate of remodeling and likelihood of HF development. This should allow a more judicious use of neurohumoral antagonists especially in subjects who do not have manifest HF.74 In others specific targeted imaging may allow timely selection of individualized treatment strategies and ensure optimization of therapeutic intervention. Similar to ACE and AII receptors, multiple other targets in the hormonal cascades can identify the likelihood of adverse and favorable remodeling.74 |
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