白英中的黄酮及酰胺类化合物

目的:对白英Solanum lyatum全草的95%乙醇提取物进行化学研究.方法:采用正相及反相硅胶柱色谱,Sephadex LH-20凝胶柱色谱,制备薄层等手段进行分离纯化,理化性质波谱数据鉴定化合物结构.结果:分离得到并鉴定了11个化合物,包括5个黄酮单体,3个酰胺单体以及3个有机酸,分别为芒柄花素(1)、香草酸(2)、染料木素(3)、芹菜素(4)、N-反式阿魏酰基酪胺(5)、香豆酰基酪胺(6)、大豆苷元(7)、咖啡酸(8)、原儿茶酸(9)、大豆苷(10)、N-反式-阿魏酰基-3-甲基多巴胺(11).结论:化合物11为首次从茄科植物中分离得到,化合物5,10为首次从茄属植物中分离得到,化合物1,3,4,7,9为首次从该植物中分离得到.

Studies on flavonoids and amides from herbs of Solanum lyratum

Objective: To investigate the chemical constituents in 95% alcohol extract of Solanum lyratum.  Method: The compounds were isolated by column chromatography over silica gel, and purified by Sephadex LH 20 column chromatography and preparative TLC. The structures were elucidated on the basis of physicochemical properties and spectral data.  Result: Eleven compounds were isolated and identified as: formononetin (1), vanillic acid (2), genistein (3), apigenin (4), N trans feruloyltyramine (5), N p coumaroyltyramine (6), daidzein (7), caffeic aicd (8), protocatechuic acid (9),daidzin (10), and N trans feruloyl 3 methyldopamine (11).  Conclusion: For the first time, Compound 11 was separated from Solanaceae plant,and compounds 5 and 10 were isolated from Solanum,and compounds 1, 3, 4, 7 and 9 were obtained from this plant for the frist time.